Study of Physicochemical Characters of in-situ Gel of Tramadole Hydrochloride

Document Type : Research Paper


Department of Pharmacy, Faculty of Medical Science, Kazan Federal University, Russia


In situ gel forming systems have been widely investigated as vehicles for sustained drug delivery. In situ gel formation occurs due to one or combination of different stimuli like pH change, temperature modulation and solvent exchange. So, In situ gelling system via different route such as oral, nasal, ophthalmic etc can be formulated. In the present research work Oral Floating Insitu gel of Tramadol Hydrochloride was formulated using Eudragit L100, Eudragit S100, Eudragit RSPO, Ethyl cellulose, HPMC K100M. The optimized batch gave drug release for 12 hrs in the polymer combination of Sodium Alginate 2% and Ethyl Cellulose 2.5%. In vivo study was performed by providing the formulation to rabbit and then X-ray was taken for the confirmation of formation of gel in stomach and floating of dosage form for 12 hrs. And it was found to be floating for more than 12 hrs. The batch was found to be stable for 6 months in accelerated stability study.


Volume 01, Issue 02
June 2017
Pages 49-56
  • Receive Date: 26 March 2017
  • Revise Date: 14 April 2017
  • Accept Date: 03 May 2020
  • First Publish Date: 03 May 2020