Department of Genetics, Hammam Laboratory, Baghdad, Iraq
10.22034/mbt.2020.120938
Abstract
In this research, poly (lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility. The therapeutic efficacy of the encapsulated naringenin (NRG-NPs) and NRG on human lung epithelial (A549) and mouse mammary (4T1) carcinoma cells proliferation was determined by MTT assays. The cytotoxicity potency was rated as follows: NRG-NPs > NRG. The antioxidant effects of the NRG and NRG-NPs were also determined by FRAP method. Our results show that NRG-NPs are cytotoxic compounds for cancer cells and anti-cancer effect can be attributed to the presence of Fe chelatory and antioxidant effects of NRG-NPs.
Khalifah, R. (2020). Flavonoid Delivery to the Target Cells through the Synthetic Nanoparticles. Medbiotech Journal, 04(03), 121-125. doi: 10.22034/mbt.2020.120938
MLA
Rassam Khalifah. "Flavonoid Delivery to the Target Cells through the Synthetic Nanoparticles". Medbiotech Journal, 04, 03, 2020, 121-125. doi: 10.22034/mbt.2020.120938
HARVARD
Khalifah, R. (2020). 'Flavonoid Delivery to the Target Cells through the Synthetic Nanoparticles', Medbiotech Journal, 04(03), pp. 121-125. doi: 10.22034/mbt.2020.120938
VANCOUVER
Khalifah, R. Flavonoid Delivery to the Target Cells through the Synthetic Nanoparticles. Medbiotech Journal, 2020; 04(03): 121-125. doi: 10.22034/mbt.2020.120938
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