The Effect of Cyclodextrin on the Action of Drugs and Their Release in the Body

Document Type : Original Article

Authors

Department of Pharmacy, Faculty of Medical Sciences, University of Kufa, Kufa, Iraq

Abstract

In some cases, in order to overcome the immune mechanisms or faster drug absorption, various routes are considered for drug administration. Regarding the physicochemical properties of many drugs, it is possible that they interact with certain molecules in the body and cause severe toxicity. On the other hand, degradation by enzymes, drug uptake by macrophages and performance reduction are among the factors that can design a unique route for drug administration. Also, the application of many useful pharmaceutical formulations is faced with restrictions due to some undesirable properties such as insolubility, poor physiochemical properties, toxicity, allergy and inflammation after administration. Since a drug redesigning process is a time-consuming, costly and complex process, attempts are being made to establish connections and interactions between drug molecules and specific carriers of bio-materials so that it reduces the undesirable properties of these molecules. Oligo-/polysaccharides such as Cyclodextrins (CDs) are promising biomaterials possessing the multi-functions and high safety and used as targeting ligands, pharmaceutical excipients, gelatinizers, etc. in the pharmaceutical fields. Regarding the hydrophilic property of the outer surface and the hydrophobic property of the inner surface, the application of cyclodextrins to create complex Drug/CDs can lead to a huge development in targeted delivery of many drugs from different administration routes. In general, increased solubility, stability, safety and bioavailability of drug molecules are among the most common applications of CDs.  

Keywords