Two-Step Route for the Preparation of Nano-Scaled Magnetic Chitosan Particles for Anticancer Drugs

Document Type : Original Article


Department of Biotechnology, Faculty of Science, Turkmen State University, Ishqabad, Turkmenistan


A new two-step route for the preparation of nano-scaled magnetic chitosan particles has been developed, different from reported one-step in situ preparation and two-step preparation method of reversedphase suspension, Triton X-100 reversed-phase water-in-oil microemulsion encapsulation method was employed in coating the pre-prepared Fe3O4 nanoparticles with chitosan. Two model anticancer drugs, Doxorubicin (DOX) and Methotrexate (MTX) were loaded effectively to functionalized MNPs through electrostatic interactions. Our developed UV method was applied for simultaneous determination of DOX and MTX. It was concluded that our findings may open the possibilities for pH-responsive targeted delivery of DOX and MTX to the cancerous tissues. 


Volume 05, Issue 01
March 2021
Pages 42-45
  • Receive Date: 16 January 2021
  • Revise Date: 03 February 2021
  • Accept Date: 26 February 2021
  • First Publish Date: 26 February 2021