Interaction of Epirubicin (Ep) and Novel CMC-CdTe / ZnS QDs nanosensor

Document Type : Original Article

Authors

1 Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran

2 Department of Plant Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, P.O.Box 14155-6343, I.R. of Iran

Abstract

Cancer named as a group of disease that causes abnormal cell growth with the ability to spread to other parts of body. Epirubicin (Ep) is one of medicine that commonly used for cancer treatment. Evaluation of low concentrations of this drug in body samples requires sensitive, rapid, and accurate analysis methods. Here we report the interaction of novel CMC-CdTe/ZnS QDs nanosensor with Ep. In the presence of 36.45 × 10−6 mol/L Ep 9.5% of fluorescence intensity of CMC-CdTe/ZnS QDs was quenched at 575 nm. This obviously illustrated that CMC -CdTe/ZnS QDs could good interact with Ep and decrease fluorescence intensity of these nanosensor.

Keywords

References

[1] M.N. Today, cancer, 2018.
[2] WHO, cancer, 2018
[3] FDA, Epirubicin Approval Letter
[4] M.I. Majeed, H. Nawaz, F.N. Arshad, Detecting the Presence of Illicit Drugs Using Biosensors, Nanobiosensors: From Design to Applications (2020) 223-253.
[5] J.S. Wilson, Sensor technology handbook, Elsevier2004.
[6] M.A. Woldu, J.L. Lenjissa, G.D. Satessa, Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor, Global Journal of Science Frontier Research: G Bio-Tech & Genetics 14 (2014).
[7] G.R. Bardajee, Z. Hooshyar, R. Soleyman, Nanocomposites of sodium alginate biopolymer and CdTe/ZnS quantum dots for fluorescent determination of amantadine, Journal of Polymer Research, 24 (2017) 128.
[8] T. Shi, H. Fu, L. Tan, J. Wang, CdTe quantum dots coated with a molecularly imprinted polymer for fluorometric determination of norfloxacin in seawater, Microchimica Acta, 186 (2019) 362.
[9] L.M. Zhang, New water‐soluble cellulosic polymers: a review, Macromolecular Materials Engineering, 286 (2001) 267-275.
[10] H. Elmizadeh, M. Soleimani, F. Faridbod, G.R. Bardajee, Fabrication and optimization of a sensitive tetracycline fluorescent nano-sensor based on oxidized starch polysaccharide biopolymer-capped CdTe/ZnS quantum dots: Box–Behnken design, Journal of Photochemistry Photobiology A: Chemistry, 367 (2018) 188-199.
[11] M.S.A. Rani, S. Rudhziah, A. Ahmad, N.S. Mohamed, Biopolymer electrolyte based on derivatives of cellulose from kenaf bast fiber, Polymers, 6 (2014) 2371-2385.

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History

  • Receive Date: 30 March 2021
  • Revise Date: 19 April 2021
  • Accept Date: 16 May 2021
  • First Publish Date: 01 June 2021

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