Introduction of Long non-coding RNA and Their Potential Role as a Biomarker in Breast Cancer

Document Type : Original Article


1 Bionovin Institute

2 University of Isfahan


Breast cancer (BC), also known as breast tumor, is major life- threatening diseases for women worldwide representing about 30% of all cancers affecting women. In order to cure and prevent the progression of such malignancy, the use of sensitive and specific biomarker1 is essential to aid the detection of breast cancer at an early stage. Furthermore, it has to be precise enough to monitor progression of the disease, and could predict the individual patient’s response to treatment. Unfortunately, markers with such characteristics have not been introduced and implemented in clinical level. Recent Bioinformatics studies have revealed a broad spectrum of noncoding RNAs called lncRNAs that are involved in breast cancer. They have a role in cell growth, apoptosis2, cell migration and invasiveness as well as cancer cell stemness. Although, their exact mechanisms and potential to serve as a biomarkers are yet to be clarified, they could be utilized for diagnostic purposes and therapeutic targets. This review is to summarize the to date information about lncRNAs that are particularly involved in breast cancer and could possibly named as a biomarker in foreseeable future.


[1] Tang X, Gao Y, Yu L, et al. Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population. Biomark Med. 2017;11(3):277‐284. doi:10.2217/bmm-2016-0238.
[2] Liu H, Li J, Koirala P, et al. Long non-coding RNAs as prognostic markers in human breast cancer. Oncotarget. 2016;7(15):20584‐20596. doi:10.18632/oncotarget.7828.
[3] Shi Y, Lu J, Zhou J, et al. Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. Biochem Biophys Res Commun. 2014;446(2):448‐453. doi:10.1016/j.bbrc.2014.02.144.
[4] De Leeneer K, Claes K. Non Coding RNA Molecules as Potential Biomarkers in Breast Cancer. Adv Exp Med Biol. 2015;867:263‐275. doi:10.1007/978-94-017-7215-0_16.
[5] Liu Y, Sharma S, Watabe K. Roles of lncRNA in breast cancer. Front Biosci (Schol Ed). 2015;7:94‐108. Published 2015 Jun 1.
[6] Jiang C, Li X, Zhao H, Liu H. Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis. Mol Cancer. 2016;15(1):62. Published 2016 Sep 29. doi:10.1186/s12943-016-0545-z.
[7] Xiaomin Zhong, Xiaowen Hu & Lin Zhang (2015) Oncogenic long noncoding RNA FAL1 in human cancer, Molecular & Cellular Oncology, 2:2, e977154, DOI:10.4161/23723556.2014.977154.
[8] Zhang K, Luo Z, Zhang Y, et al. Circulating lncRNA H19 in plasma as a novel biomarker for breast cancer. Cancer Biomark. 2016;17(2):187‐194. doi:10.3233/CBM-160630.
[9] Ye, N., Wang, B., Quan, Z.-F., Cao, S.-J., Wen, X.-T., Huang, Y., … Yan, Q.-G. (2014). Functional Roles of Long Non-coding RNA in Human Breast Cancer. Asian Pacific Journal of Cancer Prevention, 15(15), 5993–5997.
[10] Arshi A, Sharifi FS, Khorramian Ghahfarokhi M, et al. Expression Analysis of MALAT1, GAS5, SRA, and NEAT1 lncRNAs in Breast Cancer Tissues from Young Women and Women over 45 Years of Age. Mol Ther Nucleic Acids. 2018;12:751‐757. doi:10.1016/j.omtn.2018.07.014.
[11] Wang O, Yang F, Liu Y, et al. C-MYC-induced upregulation of lncRNA SNHG12 regulates cell proliferation, apoptosis and migration in triple-negative breast cancer. Am J Transl Res. 2017;9(2):533‐545. Published 2017 Feb 15.
[12] Arase M, Horiguchi K, Ehata S, et al. Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells. Cancer Sci. 2014;105(8):974‐982. doi:10.1111/cas.12454.
[13] Tuo YL, Li XM, Luo J. Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143. Eur Rev Med Pharmacol Sci. 2015;19(18):3403‐3411.
[14] Xu S, Kong D, Chen Q, Ping Y, Pang D. Oncogenic long noncoding RNA landscape in breast cancer. Mol Cancer. 2017;16(1):129. Published 2017 Jul 24. doi:10.1186/s12943-017-0696-6.
[15] Fan S, Fan C, Liu N, Huang K, Fang X, Wang K. Downregulation of the long non-coding RNA ZFAS1 is associated with cell proliferation, migration and invasion in breast cancer. Mol Med Rep. 2018;17(5):6405‐6412. doi:10.3892/mmr.2018.8707.
[16] Zheng R, Lin S, Guan L, et al. Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochem Biophys Res Commun. 2018;498(4):1002‐1008. doi:10.1016/j.bbrc.2018.03.104