Investigation of Anticancer effects of Dacarbazine Hydrogel in the Injectable Form and its Release

Document Type: Original Article

Authors

1 Cinnagen Pharmaceutical Company, Tehran, Iran

2 Islamic Azad University Pharmaceutical Science Branch, Tehran, Iran

Abstract

Cancer is currently one of the leading causes of death worldwide. Anticancer drugs can be given either by the conventional drug delivery systems including solid dosage forms, Injectable dosage forms and infusions or using the Novel drug delivery systems including targeted drug delivery dosage forms such as liposomes and nanoparticles etc.The objective of present investigation is to formulate and evaluate the In situ forming mainly Temperature induced and pH induced gelling Injectable hydrogels of an anticancer drug Dacarbazine using delivery vehicle Chitosan.All selected temperature induced and pH induced Hydrogels showed sustained drug release for a period of 10 hours. Optimized Formulation showed maximum percent drug release. In results it was found that optimized formulations are safe, effective, homogeneous, injectable and stable for delivery of Dacarbazine and this approach represents an attractive technology platform for the delivery of other clinically important Anticancer  drugs. 

Graphical Abstract

Investigation of Anticancer effects of Dacarbazine Hydrogel in the Injectable Form and its Release

Keywords