Heidary, S., Imani, M., Mostafavi, S. (2017). A Validated and Rapid HPLC Method for Quantification of Human Serum Albumin in Interferon beta-1a Biopharmaceutical Formulation. Medbiotech Journal, 01(01), 29-33. doi: 10.22034/mbt.2017.60336
Somayyeh Heidary; Mohsen Imani; Seyed Mojtaba Mostafavi. "A Validated and Rapid HPLC Method for Quantification of Human Serum Albumin in Interferon beta-1a Biopharmaceutical Formulation". Medbiotech Journal, 01, 01, 2017, 29-33. doi: 10.22034/mbt.2017.60336
Heidary, S., Imani, M., Mostafavi, S. (2017). 'A Validated and Rapid HPLC Method for Quantification of Human Serum Albumin in Interferon beta-1a Biopharmaceutical Formulation', Medbiotech Journal, 01(01), pp. 29-33. doi: 10.22034/mbt.2017.60336
Heidary, S., Imani, M., Mostafavi, S. A Validated and Rapid HPLC Method for Quantification of Human Serum Albumin in Interferon beta-1a Biopharmaceutical Formulation. Medbiotech Journal, 2017; 01(01): 29-33. doi: 10.22034/mbt.2017.60336
A Validated and Rapid HPLC Method for Quantification of Human Serum Albumin in Interferon beta-1a Biopharmaceutical Formulation
1Department of Cell and Molecular Biology, Universiti Putra Malaysia, Serdang, Malaysia
2Cinnagen Pharmaceutical Company, Karaj, Iran
3ACROSS ​Centre (Australian Centre for Research on Separation Science) University of Tasmania Hobart​, Australia
Receive Date: 16 June 2017,
Revise Date: 05 July 2017,
Accept Date: 29 August 2017
Abstract
Multiple sclerosis, or MS, is a long-lasting disease that can affect your brain, spinal cord, and the optic nerves in your eyes. It can cause problems with vision, balance, muscle control, and other basic body functions. IFN-beta treatment reduces the relapse rate in multiple sclerosis (MS), but the exact mechanism of action of the drug has remained elusive. CD73 (ecto-5'-nucleotidase) is an ectoenzyme, which produces adenosine from adenosine monophosphate (AMP) precursor by enzymatic dephosphorylation. In this study, a validated and rapid HPLC method for quantification of human serum albumin in interferon beta-1a biopharmaceutical formulation was developed and linearity, robustness, specificity, accuracy and precision of samples were determined.
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