The Possible Biological Effects of Long-term Stress on Depression

Document Type : Research Paper


Department of Pharmacy, University of Isfahan, Iran


Depression is a disorder in which a person is unfit physically and mentally. WHO stated it is the fourth major cause of passing disable life. It reduces individual’s productive life and leads to premature mortality. From last 20 years an extensive research has been done to find relationship between life stress and depression. Stress is not the sole causative factor, but genetic as well as biological changes in the depressed individual play important role in the onset of depression. Other predisposing factors for depression include childhood stress such as ignorance by family, early loss of parents, physical or sexual abuse, no social support, financial loss etc. Stressful life events can lead to depression has been explored by many researchers and concluded that stressful life-events can arouse or trigger depression episodes in susceptible individuals.


Volume 02, Issue 04
December 2018
Pages 149-152
  • Receive Date: 02 October 2018
  • Revise Date: 22 October 2018
  • Accept Date: 10 November 2018
  • First Publish Date: 01 December 2018